Gene: LCORL-regulatory unit

General Information:

  • The height in animals depends on different factors such as genes, environment and their combination.
  • One genetic variant has been identified which has a strong influence on the height in warmblood horses.
  • One basepair in the LCORL-regulatory unit (in the third chromosome) determines in a large part what height a horse will reach.
  • This test enables breeders to estimate their horses height before they are fully grown (accuracy: 70% ; +/- 5 cm).

Possible Genotypes:

Genotypes T/T C/T C/C
Effects: “Normal”: Warmbloods will reach a height of 159 cm (+/- 5 cm).

Depending on mating, offspring will be of “normal” (T/T) or “medium” (C/T) height.

“Medium”: Warmbloods will reach a height of 164 cm (+/- 5 cm).

Depending on mating, all three genotypes are possible (T/T, C/T, C/C).

“Tall”: Warmbloods will reach a height of 169 cm (+/- 5 cm).

Depending on mating, offspring will be of “medium” (C/T) height or “tall” (C/C) height.

 

Recommendations:

  • This variant has only a strong influence on warmbloods. Other horses or ponies might not reach the estmated heights if showing the respective genotypes. Most pony breeds or lighter riding horse breeds (e.g. Arabian horses) have the T/T genotype.
  • In these breeds other genome regions have a stronger impact on their height. These are still undisclosed. But one variant in the HMGA2 gene has shown a similar influence on Shetland Ponies. See the Height test – Pony for further information.

Testinformation: This tests detects the change of a single basepair in die LCORL regulatory unit of the third chromosome.

Metzger, J., Schrimpf, R., Philipp, U., Distl, O.: Expression levels of LCORL are associated with body size in horses. PLoS One 8:e56497, 2013. Pubmed reference: 23418579. DOI: 10.1371/journal.pone.0056497.

Tetens, J., Widmann, P., Kühn, C., Thaller, G.: A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses. Anim Genet 44:467-71, 2013. Pubmed reference: 23418885. DOI: 10.1111/age.12031.

Makvandi-Nejad, S., Hoffman, G.E., Allen, J.J., Chu, E., Gu, E., Chandler, A.M., Loredo, A.I., Bellone, R.R., Mezey, J.G., Brooks, S.A., Sutter, N.B.: Four loci explain 83% of size variation in the horse. PLoS One 7:e39929, 2012. Pubmed reference: 22808074. DOI: 10.1371/journal.pone.0039929.

Signer-Hasler, H., Flury, C., Haase, B., Burger, D., Simianer, H., Leeb, T., Rieder, S.: A genome-wide association study reveals loci influencing height and other conformation traits in horses. PLoS One 7:e37282, 2012. Pubmed reference: 22615965. DOI: 10.1371/journal.pone.0037282.

Further information is available at Online Mendelian Inheritance in Animals.

Breeds:
Test #: H218
Sample: Blood, Hair
Price: 35 € (net)
Time required: 7-10 days