skip to Main Content
+49 7071 565 44 850 info@centerforanimalgenetics.com Facebook

→ Fatal infections due to a deficient immune system

Symptoms:

  • Severe infections

General Information:

  • Foals appear healthy at birth, but usually die of infection within the first 6 months.
  • Improper development of cells of the immune system (T- and B cells) causes severe, non-specific infections → usually fatal.

Inheritance: autosomal recessive

→ Only horses with two copies of the variant (scid/scid) are affected. Horses with only one copy of the variant (N/scid) are clinically healthy carriers.

Possible Genotypes:

Genotype The horse is:
Effects:
N/N normal. The horse has no copies of the genetic variant causative for SCID and therefore cannot pass it on to its offspring.
N/scid a carrier. The horse is clinically healthy. The genetic variant will be passed on to the offspring with a probability of 50%.
scid/scid affected. If the horse lives long enough to reproduce, the variant will be passed on to all offspring. All offspring will be carriers (N/scid).

 

Recommendations:

  • Carriers may be bred to normal animals (N/scid x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or normal.
  • Breeding two carriers (N/scid x N/scid) is not recommended due to the possibility of 25% of the offspring being affected.
  • Affected animals (scid/scid) should not be used for breeding.

Test information: This test detects the deletion in the DNAPK gene.

Shin, E.K., Perryman, L.E., Meek, K.: A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol 158:3565-9, 1997. Pubmed reference: 9103416.

Further information is available at Online Mendelian Inheritance in Animals.

Breeds affected:

Arabian and related breeds

Test #: H111

Samples: Blood, Hair

Price: 35 € (net)

Time required: 7-10 days

Back To Top