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Breeds: Many: Portuguese Waterdog, Lagotta Romagnolo , Poodle, “Doodles”, Soft Coated Wheaten Terrier, Dachshund, Brussels Griffon, Chinese Crested Dog, German Wirehair Pointer, Havana Silk, Havanese, Irish Terrier, Schnauzer, Scottish Terrier, Tibetan Terrier, etc.

Samples Accepted: Blood, Buccal Swabs

Trait Information: Improper Coat/Furnishings is a trait of hair length and texture.  Dogs with one or two copies of the allele have distinctive long eyebrow and mustache hair.  In breeds in which the trait is desirable, this phenotype is known as “Furnishings”.  In other breeds, the trait is expected; a deviation from it is a fault, and it is termed “improper coat”.

Inheritance Information: IC-F is autosomal dominant, meaning that animals with just one copy of this allele will show the phenotype, and 50% of their offspring will also show this trait.  Animals with 2 copies of the allele will also show the trait, but 100% of their offspring will show the trait.

The possible genotypes are:
ic-f/ic-f The dog has improper coat (no furnishings), and it cannot produce offspring with furnishings unless bred to another dog with furnishings.

ic-f/IC-F The dog has furnishings (longer eyebrow and mustache hair), but 50% of its offspring may lack  furnishings (show improper coat).

IC-F/IC-F The dog has furnishings (longer eyebrow and mustache hair), and cannot produce offspring without this trait (ie. will not produce any offspring with improper coat).

Recommendations:
– All dogs can be used for breeding, to maintain breed diversity.  Dogs with improper coat/no furnishings (ic-f/ic-f) should be bred to dogs with two copies of the furnishings allele (IC-F/IC-F) in order for all offspring to have normal coats (furnishings).  Breeding to a dog with furnishings but heterozygous for the trait (IC-F/ic-f) will produce 50% pups with normal (furnished) coats and 50% with improper (unfurnished) coats.

Test Information: This mutation test identifies an insertion in the RSPO2 gene.

Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K.: Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279. DOI: 10.1371/journal.pgen.1002316.

Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., Wong, A., Mosher, D.S., Elkahloun, A.G., Spady, T.C., André, C., Lark, K.G., Cargill, M., Bustamante, C.D., Wayne, R.K., Ostrander, E.A.: Coat variation in the domestic dog is governed by variants in three genes. Science 326:150-3, 2009. Pubmed reference: 19713490. DOI: 10.1126/science.1177808.

Parker, HG., Chase, K., Cadieu, E., Lark, KG., Ostrander, EA.: An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered 101:612-7, 2010. Pubmed reference: 20562213. DOI: 10.1093/jhered/esq068.

Further information is available: Furnishings: Online Mendelian Inheritance in Animals and Improper Coat: Online Mendelian Inheritance in Animals.

Test #: D202

Cost: 35 € (excl. VAT)

Time: 7-10 days

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