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Breeds: Chinese Crested Dog, Mexican Hairless Dog (Xoloitzcuintli), Peruvian Hairless Dog (Inca Hairless)

Samples Accepted: Blood, Buccal Swabs

Trait Information: Ectodermal dysplasia results in varying amounts of hairlessness over all or most of the body; tufts may be present on the head, feet, and tail.  Teeth may be abnormal or some might be missing.

Inheritance Information: Hairlessness is autosomal dominant, meaning that animals with just one copy of this allele will show the phenotype, and 50% of their offspring will also show this trait. Hairlessness is homozygous lethal, thus animals with two copies of the allele will not be born.

The possible genotypes are:
n/n The dog has a normal coat (in Chinese Crested, this is known as Powder Puff), and normal teeth.

H/n The dog is all or mostly hairless, and may have abnormal teeth.

Recommendations:
– All dogs can be used for breeding, to maintain genetic diversity.  If two Hairless (H/n x H/n) are bred, 25% of the offspring will be hairless embryonic lethal (H/H) and will not be born.  50% will be hairless (H/n) and 25% will have hair (n/n). Litter sizes will thus be smaller than normal, as 25% of the embryos will not carry to term.  The live offspring will therefore be approximately 33% normally haired and 66% hairless.  Breeding hairless (H/n) to normally haired (n/n) dogs will produce 50% hairless and 50% normally haired offspring.

Test Information: This mutation test identifies a duplication in the FOXI3 gene.

Drögemüller, C., Karlsson, E.K., Hytönen, M.K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad-Toh, K., Leeb, T.: A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science 321:1462, 2008. Pubmed reference: 18787161. DOI: 10.1126/science.1162525

Further information is available at the Online Inheritance in Animals website.

Test #: D204

Cost: 35 € (excl. VAT)

Time: 7-10 days

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