Breeds Affected: Beagle
Samples Accepted: Blood, Buccal Swabs
Disease Information: POAG is caused by an increase of pressure within the eye, eventually leading to blindness.
Inheritance Information: POAG is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.
The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/poag The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/poag carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
poag/poag The dog is affected. If bred to a normal animal, 100% of the offspring will be carriers. If bred to an N/poag carrier, 50% of the offspring will be carriers and 50% will be affected.
– Carriers may be bred to normal animals (N/poag x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/poag x N/poag) is not recommended due to the possibility of 25% of the offspring being affected.
– Affected animals (poag/poag) should not be used for breeding.
Test Information: This mutation test identifies a single base change in the ADAMTS10 gene.
Kuchtey, J., Olson, L.M., Rinkoski, T., Mackay, E.O., Iverson, T.M., Gelatt, K.N., Haines, J.L., Kuchtey, R.W.: Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306, 2011. Pubmed reference: 21379321. DOI: 10.1371/journal.pgen.1001306.
Kuchtey, J., Kunkel, J., Esson, D., Sapienza, J.S., Ward, D.A., Plummer, C.E., Gelatt, K.N., Kuchtey, R.W. : Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in Beagles. Invest Ophthalmol Vis Sci 54:1881-6, 2013. Pubmed reference: 23422823. DOI: 10.1167/iovs.12-10796.
Further information is available at the Online Mendelian Inheritance in Animals website.