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Breeds Affected: Coton de Tuléar

Samples Accepted: Blood, Buccal Swabs

Disease Information: Primary Hyperoxaluria (PH) is a disease in which oxalate crystals form in the kidney, resulting in sudden illness leading to death in 3-4 week old pups.

Inheritance Information: PH is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.

The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/ph The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/ph carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
ph/ph The dog is affected, and will not live long enough to reproduce.

Recommendations:
– Carriers may be bred to normal animals (N/ph x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/ph x N/ph) is not recommended due to the possibility of 25% of the offspring being affected.

Test Information: This mutation test identifies a single base pair change in the AGXT gene.

Vidgren, G., Vainio-Siukola, K., Honkasalo, S., Dillard, K., Anttila, M., Vauhkonen, H.: Primary hyperoxaluria in Coton de Tulear. Anim Genet 43:356-61, 2012. Pubmed reference: 22486513. DOI: 10.1111/j.1365-2052.2011.02260.x.

Further information is available at the Online Mendelian Inheritance in Animals website

Test #: D111

Cost: 55 € (excl. VAT)

Time: 7-10 days

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