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→ Life-threatening bleeding disorder following injuries/surgery

Symptoms:

  • Extreme bleeding after injuries or surgery

General Information:

  • Postoperative Hemorrhage is caused by a change in the P2Y12 gene.
  • Affected dogs may remain undiagnosed if no bigger injury occurs and no surgery is performed.
  • In case of a severe injury or a surgery, this disease may be life-threatening due to extreme blood loss.

Inheritance: autosomal recessive

→ Only animals with two copies of the variant (p2y12/p2y12) are affected. Animals with only one copy of the variant (N/p2y12) are clinically normal carriers.

Possible Genotypes:

Genotype The dog is:
Effects:
N/N normal. The dog has no copy of the genetic variant causative for Postoperative Hemorrhage and therefore cannot pass it on to its offspring.
N/p2y12 a carrier.
The dog is clinically healthy. The genetic variant causative for Postoperative Hemorrhage will be passed on to its offspring with a probability of 50%.
p2y12/p2y12 affected. The genetic variant causative for Postoperative Hemorrhage will be passed on to all its offspring. All offspring will be carriers (N/p2y12).

 

Recommendations:

  • Carriers may be bred to normal animals (N/p2y12 x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
  • Breeding two carriers (N/p2y12 x N/p2y12) is not recommended due to the possibility of 25% of the offspring being affected.
  • Affected animals (p2y12/p2y12) should not be used for breeding.

Testinformation: This test detects the deletion in the P2Y12 gene.

Boudreaux, MK., Martin, M. : P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog. Vet Clin Pathol 40:202-206, 2011. Pubmed reference: 21554368. DOI: 10.1111/j.1939-165X.2011.00318.x.

Further information are available at: Online Mendelian Inheritance in Animals.

Breeds affected:

Test #: D141

Samples: Blood, Buccal Swab

Price: 35 € (excl. VAT)

Time required: 7-10 days

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