- Extreme bleeding after injuries or surgery
- Postoperative Hemorrhage is caused by a change in the P2Y12 gene.
- Affected dogs may remain undiagnosed if no bigger injury occurs and no surgery is performed.
- In case of a severe injury or a surgery, this disease may be life-threatening due to extreme blood loss.
Inheritance: autosomal recessive
→ Only animals with two copies of the variant (p2y12/p2y12) are affected. Animals with only one copy of the variant (N/p2y12) are clinically normal carriers.
|Genotype||The dog is:
|N/N||normal.||The dog has no copy of the genetic variant causative for Postoperative Hemorrhage and therefore cannot pass it on to its offspring.
||The dog is clinically healthy. The genetic variant causative for Postoperative Hemorrhage will be passed on to its offspring with a probability of 50%.
|p2y12/p2y12||affected.||The genetic variant causative for Postoperative Hemorrhage will be passed on to all its offspring. All offspring will be carriers (N/p2y12).
- Carriers may be bred to normal animals (N/p2y12 x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
- Breeding two carriers (N/p2y12 x N/p2y12) is not recommended due to the possibility of 25% of the offspring being affected.
- Affected animals (p2y12/p2y12) should not be used for breeding.
Testinformation: This test detects the deletion in the P2Y12 gene.
Boudreaux, MK., Martin, M. : P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog. Vet Clin Pathol 40:202-206, 2011. Pubmed reference: 21554368. DOI: 10.1111/j.1939-165X.2011.00318.x.
Further information are available at: Online Mendelian Inheritance in Animals.