Breeds Affected: Greyhound
Samples Accepted: Blood, Buccal Swabs
Disease Information: Polyneuropathy is a chronic, progressive disease that in Greyhounds is usually diagnosed between 3-9 months of age. Affected animals show symptoms including exercise intolerance and gait abnormalities leading to para- or tetraparesis, muscle atrophy, and laryngeal paralysis.
Inheritance Information: Polyneuropathy is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.
The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/p The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/p carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
p/p The dog is affected. If bred to a normal animal, 100% of the offspring will be carriers. If bred to an N/p carrier, 50% of the offspring will be carriers and 50% will be affected.
– Carriers may be bred to normal animals (N/p x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/p x N/p) is not recommended due to the possibility of 25% of the offspring being affected.
– Affected animals (p/p) should not be used for breeding.
Test Information: This test identifies a 10 base pair deletion in exon 15 of the NDRG1 gene.
Drogemuller, C., Becker, D., Kessler, B., Kemter, E., Tetens, J., Jurina, K., Jaderlund, KH., Flagstad, A., Perloski, M., Lindblad-Toh, K., Matiasek, K.: A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010. Pubmed reference: 20582309. Doi: 10.1371/journal.pone.0011258.
Further information is available at the Online Mendelian Inheritance in Animals website.