Breeds Affected: Alaskan Malamute
Samples Accepted: Blood, Buccal Swabs
Disease Information:Polyneuropathy is a chronic, progressive disease that in Alaskan Malamutes generally show clinical signs between 7-18 months of age. Affected animals show symptoms including exercise intolerance and gait abnormalities leading to para- or tetraparesis, muscle atrophy, and laryngeal paralysis.
Inheritance Information: Polyneuropathy is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.
The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/p The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/p carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
p/p The dog is affected. If bred to a normal animal, 100% of the offspring will be carriers. If bred to an N/p carrier, 50% of the offspring will be carriers and 50% will be affected.
– Carriers may be bred to normal animals (N/p x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/p x N/p) is not recommended due to the possibility of 25% of the offspring being affected.
– Affected animals (p/p) should not be used for breeding.
Test Information: This test identifies a single base pair change in exon 4 of the NDRG1 gene.
Bruun, C.S., Jäderlund, K.H., Berendt, M., Jensen, K.B., Spodsberg, E.H., Gredal, H., Shelton, G.D., Mickelson, J.R., Minor, K.M., Lohi, H., Bjerkås, I., Stigen, O., Espenes, A., Rohdin, C., Edlund, R., Ohlsson, J., Cizinauskas, S., Leifsson, P.S., Drögemüller, C., Moe, L., Cirera, S., Fredholm, M.: A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8:e54547, 2013. Pubmed reference: 23393557. DOI: 10.1371/journal.pone.0054547.
Further information is available at the Online Mendelian Inheritance in Animals website.