Breeds Affected: Pug

Samples Accepted: Blood, Buccal Swab

Disease Information: May-Hegglin Anomaly is a rare disorder of platelet formation (including macrothrombocytosis and thrombocytopenia) which may be mistaken for immune-mediated thrombocytopenia.

Inheritance Information: May-Hegglin Anomaly is believed to be autosomal dominant, meaning that animals with one copy of this allele will be affected. 50% of their offspring will also be affected.

The possible genotypes are:
n/n The dog is normal, and cannot produce MHA-affected offspring.

n/MHA The dog is affected with MHA, and 50% of the offspring will be affected.

MHA/MHA The dog is affected with MHA, and 100% of the offspring will also be affected.

Recommendations:
– Affected animals (n/MHA, MHA/MHA) should not be used for breeding.

Test Information: This mutation test identifies a single base change in the MYH9 gene.

Flatland, B., Fry, M.M., Baek, S.J., Bahn, J.H., LeBlanc, C.J., Dunlap, J.R., Carroll, R.C., Kosiba, D.J., Millsaps, D.J., Schleis, S.E.: May-Hegglin anomaly in a dog. Vet Clin Pathol 40:207-14, 2011. Pubmed reference: 21554370. DOI: 10.1111/j.1939-165X.2011.00320.x.

Further information is available at the Online Mendelian Inheritance in Animals website.

Test #: D150
Cost: 35 € (excl. VAT)
Time: 7-10 days