Breeds Affected: German Shepherd Dog
Samples Accepted: Blood, Buccal Swabs
Disease Information: LAD3 is a blood disorder characterized by a predisposition to infection and fever, lameness, and abnormal bleeding, including hemorrhage.
Inheritance Information: LAD3 is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.
The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/lad3 The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/lad3 carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
lad3/lad3 The dog is affected. If bred to a normal animal, 100% of the offspring will be carriers. If bred to an N/lad3 carrier, 50% of the offspring will be carriers and 50% will be affected.
– Carriers may be bred to normal animals (N/lad3 x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/lad3 x N/lad3) is not recommended due to the possibility of 25% of the offspring being affected.
– Affected animals (lad3/lad3) should not be used for breeding.
Test Information: This mutation test identifies a 12 base insertion in the FERMT3 (previously Kindlin-3) gene.
Boudreaux, MK., Wardrop, KJ., Kiklevich, V., Felsburg, P., Snekvik, K.: A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost 103:475-7, 2010. Pubmed reference: 20126836. DOI: 10.1160/TH09-09-0571.
Further information is available at the Online Mendelian Inheritance in Animals website.