Breeds Affected: Beagle, American Foxhound
Samples Accepted: Blood, Buccal Swabs
Disease Information: Dogs with hypocatalasia show a reduction of catalase enzyme activity in the red blood cells. Affected animals may have progressive gangrene of the mouth.
Inheritance Information: Hypocatalasia is autosomal recessive, meaning that animals with two copies of this allele will be affected. Animals with one copy of the gene will be clinically-normal carriers.
The possible genotypes are:
N/N The dog is normal, and cannot produce affected offspring.
N/hyp The dog is a carrier, and can pass the allele on to approximately 50% of any offspring. If bred to another N/hyp carrier, approximately 25% of the offspring will be normal, 50% will be carriers, and 25% will be affected.
hyp/hyp The dog is affected. If bred to a normal animal, 100% of the offspring will be carriers. If bred to an N/hyp carrier, 50% of the offspring will be carriers and 50% will be affected.
– Carriers may be bred to normal animals (N/hyp x N/N) without any risk of producing affected offspring. The offspring should be tested before breeding to determine if they are carriers or normal.
– Breeding two carriers (N/hyp x N/hyp) is not recommended due to the possibility of 25% of the offspring being affected.
– Affected animals (hyp/hyp) should not be used for breeding.
Test Information: This mutation test identifies a single base change in the CAT gene.
Donner, J., Kaukonen, M., Anderson, H., Möller, F., Kyöstilä, K., Sankari, S., Hytönen, M., Giger, U., Lohi, H. :Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders. PLoS One 11:e0161005, 2016. Pubmed reference: 27525650. DOI: 10.1371/journal.pone.0161005.
Nakamura, K., Watanabe, M., Takanaka, K., Sasaki, Y., Ikeda, T.: cDNA cloning of mutant catalase in acatalasemic beagle dog: single nucleotide substitution leading to thermal-instability and enhanced proteolysis of mutant enzyme International Journal of Biochemistry & Cell Biology 32:1183-1193, 2000. Pubmed reference: 11137458.
Further information is available at the Online Mendelian Inheritance in Animals website.