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Color: Dilution/dilute causes an animal’s hair to be lighter in color than the base colors encode.

Samples Accepted: Blood, Buccal Swabs

Locus Information: D
Dilution of coat color is due to fewer color-containing cells (melanocytes) being distributed in the hair shaft. It affects both dark (eumelanin) and light (phaeomelanin) pigments. Dilution is recessive, therefore, when homozygous, black cats appear grey (called blue), chocolate cats appear light brown (called lilac), cinnamon cats appear fawn, and orange cats appear cream.

Test Information: This mutation test identifies a one base pair deletion in exon 2 of the MLPH gene.

Ishida, Y., David, V.A., Eizirik, E., Schäffer, A.A., Neelam, B.A., Roelke, M.E., Hannah, S.S., O’brien, S.J., Menotti-Raymond, M.: A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat. Genomics 88:698-705, 2006. Pubmed reference: 16860533. Doi: 10.1016/j.ygeno.2006.06.006.

Further information is available at the Online Mendelian Inheritance in Animals website.

Test #: C206

Cost: 35 € (excl. VAT)

Time: 7-10 days

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