Samples Accepted: Blood, Buccal Swabs
Locus Information: B series
The B series is caused by two mutations in the same gene. Having a copy of the wild-type allele (B) results in a black colored animal (B/B, B/b, B/bl). When no wild-type allele is present, having a copy of the b allele gives the color of brown known as chocolate (b/b, b/bl). Two copies of the bl allele results in a lighter brown color called cinnamon.
Chocolate: Test # C202: This mutation test identifies a single base pair change in intron 6 of the TYRP1 gene.
Cinnamon: Test # C203: This mutation test identifies a stop mutation in exon 2 of the TYRP1 gene.
Lyons, LA., Foe, IT., Rah, HC., Grahn, RA.: Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm Genome 16:356-66, 2005. Pubmed reference: 16104383.
Further information is available at the Online Mendelian Inheritance in Animals website.