CAG GmbH and collaborators at Clemson University and the University of California San Diego have identified a mutation in Boston terriers that causes limb-girdle muscular dystrophy (LGMD). Affected dogs usually show symptoms by 2-4 months of age, including muscle wasting, a stiff and stilted gait, an enlarged tongue and drooling, difficulty swallowing, and frequent vomiting. Affected pups are usually euthanized by 8-10 months of age.
Carrier dogs are clinically normal, so it is possible for a disease allele to be present in a population for many generations without being detected. It is currently not known how common this allele is in the Boston terrier population.
Our laboratory is collecting samples from normal and affected Boston terriers to assess allele frequency in the population. Samples need to be received by 10.12.2015 to be included in the study. All information will be kept confidential, and results will be returned only to the owner who submitted the sample.
If you have a purebred Boston terrier and would consider taking part in this study, please fill out our Sample Recruitment Contact Form or email us at email@example.com and we will send you a free sample collection kit and instructions.