Severe Combined Immunodeficiency Disease (SCID)
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→ Fatal infections due to a deficient immune response.
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Any information you include here is optional, but will be included on the certificate of results (except “Additional Info”).
- Product Information
- General Information
- Inheritance and Genotypes
|Affected breeds:||Arabian Horse and related breeds|
|Description:||Severe Combined Immunodeficiency Disease Genetic Testing
This test detects the deletion in the DNAPK gene.
|Time:||10 – 14 days|
- Foals appear healthy at birth, but usually die of infection within the first 6 months.
- Improper development of cells of the immune system (T- and B cells) causes severe, non-specific infections → usually fatal.
- Severe infections
Inheritance and Genotypes
→ SCID is an autosomal recessive hereditary disease, meaning that horses with only one copy of the genetic variant (N/scid) are clinically normal carriers while horses with two copies of the genetic variant (scid/scid) are affected.
|Genotype:||The horse is:||Effects:|
|N/N||normal.||The horse does not have any copies of the genetic variant causative for SCID and therefore cannot pass it on to any offspring.|
||The horse is clinically normal. The genetic variant causative for SCID will be passed on to its offspring with a probability of 50%. These foals will also be carriers (N/scid).
|scid/scid||affected.||If the horse lives long enough to reproduce, the variant will be passed on to all offspring. All offspring will be carriers (N/scid).|
- Carriers may be bred to normal animals (N/scid x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or normal.
- Breeding two carriers (N/scid x N/scid) is not recommended due to the possibility of 25% of the offspring being affected.
- Affected animals (scid/scid) should not be used for breeding.