Naked Foal Syndrome (NFS)
35,00 € Special Price:
excl. 19% VAT
→ Lethal hairlessness in Akhal-Teke horses.
Instructions for ordering:
- Enter the information of the first horse for which you want to order the test
- Add to cart
- Go to cart to check out, or
- Enter the information for a second horse
- For sample collection follow the instructions here.
- You can use this template to send in hair samples.
- Please also send the completed order form together with the samples.
For a breeder or veterinarian discount please contact us before ordering.
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- The variation of the ST14 gene leads to hairlessness in horses and early death of affected foals.
- Affected horses usually die shortly after birth or before the age of 3 years.
- The exact cause for the early death is yet unknown.
- NFS was first reported in 1938.
- Sparse coat (very little or no hair)
- Ichthyosis (dry, thickened skin)
Inheritance and Genotypes
→ NFS is an autosomal recessive hereditary disease, meaning that horses with only one copy of the genetic variant (N/nfs) are clinically normal carriers while horses with two copies of the genetic variant (nfs/nfs) are affected.
|Genotype:||The horse is:||Effects:|
|N/N||normal.||The horse does not have any copies of the genetic variant causative for NFS and therefore cannot pass it on to any offspring.|
||The horse is clinically normal. The genetic variant causative for NFS will be passed on to its offspring with a probability of 50%. These foals will also be carriers (N/nfs).
|nfs/nfs||affected.||If the horse lives long enough to reproduce the genetic variant causative for NFS will be passed on to all offspring. All offspring will be carriers (N/nfs).|
- Carriers may be bred to normal animals (N/nfs x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or genetically normal.
- Breeding two carriers (N/nfs x N/nfs) is not recommended due to the possibility of 25% of the offspring being affected.
- Affected animals (nfs/nfs) should not be used for breeding.
Bauer, A., Hiemesch, T., Jagannathan, V., Neuditschko, M., Bachmann, I., Rieder, S., Mikko, S., Penedo, M.C., Tarasova, N., Vitková, M., Sirtori, N., Roccabianca, P., Leeb, T., Welle, M.M. : A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome. G3 (Bethesda) 7:1315-1321, 2017. Pubmed reference: 28235824. DOI: 10.1534/g3.117.039511.
Further information is available at Online Mendelian Inheritance in Animals.