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Incontinentia Pigmenti (IP)

35,00 

→ Coat pattern with negative effects on skin, teeth and eyes.


Instructions for ordering:

  1. Enter the information of the first horse for which you want to order the test
  2. Add to cart
  3. Go to cart to check out, or
  4. Enter the information for a second horse
  5. For sample collection follow the instructions here.
  6. You can use this template to send in hair samples.
  7. Please also send the completed order form together with the samples.

For a breeder or veterinarian discount please contact us before ordering.

Any information you include here is optional, but will be included on the certificate of results (except “Additional Info”).

Enter the name of your animal
Enter your animal's date/year of birth
Enter the breed name
Enter the registration number if known
Enter the microchip number
Is there anything else you would like to tell us about your horse? Reason for testing, symptoms etc.?

General Information

  • IP may be mistaken for a “normal” coat pattern.
  • Mares show the under “Symptoms” described phenotype.
  • Symptoms manifest themselves over time.
  • Stallions with this variant will be aborted during pregnancy.

Symptoms

  • Pattern following the lines of Blaschko (going down from the spine on each side of the horse)
  • Anomalies of eyes, teeth and hooves
  • Sparse mane and tail
  • Hairless patches distributed over entire body
  • Itchy skin lesions

Inheritance and Genotypes

→ IP is an X-linked dominant hereditary disease, meaning that males and females with only one copy of the genetic variant are affected (XIP/X and XIP/Y). Males with one copy of the genetic variant (XIP/Y) causative for IP are aborted during pregnancy.

Genotype: The horse is: Effects:
X/X a normal mare. The horse does not have any copies of the genetic variant causative for IP and therefore cannot pass it on to any offspring.
XIP/X an affected mare. The genetic variant causative for IP will be passed on to its offspring with a probability of 50%. These 50% will also be affected males or females.
X/Y a normal stallion. The horse has no copies of the genetic variant causitive for IP and therefore cannot pass it on to its offspring.
XIP/Y an affected stallion. The foal is affected and will be aborted during pregnancy.

Recommendations

  • To reduce distribution of IP, affected mares (XIP/X) should not be used for breeding.

References

Towers, R.E., Murgiano, L., Millar, D.S., Glen, E., Topf, A., Jagannathan, V., Drögemüller, C., Goodship, J.A., Clarke, A.J., Leeb, T.: A nonsense mutation in the IKBKG gene in mares with incontinentia pigmenti. PLoS One 8:e81625, 2013. Pubmed reference: 24324710. DOI: 10.1371/journal.pone.0081625.

Further information is available at Online Mendelian Inheritance in Animals.

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