Incontinentia Pigmenti (IP)
excl. 19% VAT
→ Coat pattern with negative effects on skin, teeth and eyes.
Instructions for ordering:
- Enter the information of the first horse for which you want to order the test
- Add to cart
- Go to cart to check out, or
- Enter the information for a second horse
- For sample collection follow the instructions here.
- You can use this template to send in hair samples.
- Please also send the completed order form together with the samples.
For a breeder or veterinarian discount please contact us before ordering.
Any information you include here is optional, but will be included on the certificate of results (except “Additional Info”).
- IP may be mistaken for a “normal” coat pattern.
- Mares show the under “Symptoms” described phenotype.
- Symptoms manifest themselves over time.
- Stallions with this variant will be aborted during pregnancy.
- Pattern following the lines of Blaschko (going down from the spine on each side of the horse)
- Anomalies of eyes, teeth and hooves
- Sparse mane and tail
- Hairless patches distributed over entire body
- Itchy skin lesions
Inheritance and Genotypes
→ IP is an X-linked dominant hereditary disease, meaning that males and females with only one copy of the genetic variant are affected (XIP/X and XIP/Y). Males with one copy of the genetic variant (XIP/Y) causative for IP are aborted during pregnancy.
|Genotype:||The horse is:||Effects:|
|X/X||a normal mare.||The horse does not have any copies of the genetic variant causative for IP and therefore cannot pass it on to any offspring.|
|XIP/X||an affected mare.||The genetic variant causative for IP will be passed on to its offspring with a probability of 50%. These 50% will also be affected males or females.
|X/Y||a normal stallion.||The horse has no copies of the genetic variant causitive for IP and therefore cannot pass it on to its offspring.|
|XIP/Y||an affected stallion.||The foal is affected and will be aborted during pregnancy.|
- To reduce distribution of IP, affected mares (XIP/X) should not be used for breeding.
Towers, R.E., Murgiano, L., Millar, D.S., Glen, E., Topf, A., Jagannathan, V., Drögemüller, C., Goodship, J.A., Clarke, A.J., Leeb, T.: A nonsense mutation in the IKBKG gene in mares with incontinentia pigmenti. PLoS One 8:e81625, 2013. Pubmed reference: 24324710. DOI: 10.1371/journal.pone.0081625.
Further information is available at Online Mendelian Inheritance in Animals.