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Hyperkaliemic Periodic Paralysis (HYPP)

35,00 

 → Temporary paralysis in Quarter Horses.


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Product Information

Affected breeds: Quarter Horse and related breeds
Test #: H107
Description: Hyperkaliemic Periodic Paralysis Genetic Testing

This test detects the change in the SCN4A gene.

Samples: Hair, Blood
Time: 10 – 14 days

General Information

  • Symptoms can vary strongly in severity.
  • May be life-threatening when heart or lungs are affected by paralysis.
  • Homozygous horses (animals with two copies of the genetic variant) show more severe symptoms than heterozygous individuals (animals with only one copy).
  • Symptoms may occur more frequently after changes in diet, stress or transportation.
  • Inproper signalling between brain and muscles/organs causing the periodic paralysis.
  • Symptoms may be reduced with potassium-deficient diet (avoid Lucerne/Alfalfa in hay)
  • HYPP can be traced back to the sire “Impressive”.

Symptoms

  • General weakness
  • Periodic tremors and paralysis
  • Respiratory problems (noise while breathing)
  • Heavily muscled

Inheritance and Genotypes

→ HYPP is an autosomal dominant hereditary disease, meaning that horses with one or two copies of the genetic variant (n/HYPP or HYPP/HYPP) are affected.

Genotype: The horse is: Effects:
n/n normal. The horse does not have any copies of the genetic variant causative for HYPP and therefore cannot pass it on to any offspring.
n/HYPP affected (heterozygous). The genetic variant causative for HYPP will be passed on to its offspring with a probability of 50%. These 50% will also be affected (n/HYPP).
HYPP/HYPP affected (homozygous). The genetic variant causative for HYPP will be passed on to all offspring. All offspring will also be affected (n/HYPP).

Recommendations

  • Affected animals (n/HYPP or HYPP/HYPP) should not be used for breeding.

References

Rudolph, J. A., Spier, S. J., Byrns, G., Rojas, C. V., Bernoco, D., & Hoffman, E. P. (1992). Periodic paralysis in quarter horses: a sodium channel mutation disseminated by selective breeding. Nature Genetics, 2(2), 144-147. doi: 10.1038/ng1092-144.

Further information is available at Online Mendelian Inheritance in Animals.

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