Hyperkaliemic Periodic Paralysis (HYPP)
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→ Temporary paralysis in Quarter Horses.
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- Product Information
- General Information
- Inheritance and Genotypes
|Affected breeds:||Quarter Horse and related breeds|
|Description:||Hyperkaliemic Periodic Paralysis Genetic Testing
This test detects the change in the SCN4A gene.
|Time:||10 – 14 days|
- Symptoms can vary strongly in severity.
- May be life-threatening when heart or lungs are affected by paralysis.
- Homozygous horses (animals with two copies of the genetic variant) show more severe symptoms than heterozygous individuals (animals with only one copy).
- Symptoms may occur more frequently after changes in diet, stress or transportation.
- Inproper signalling between brain and muscles/organs causing the periodic paralysis.
- Symptoms may be reduced with potassium-deficient diet (avoid Lucerne/Alfalfa in hay)
- HYPP can be traced back to the sire “Impressive”.
- General weakness
- Periodic tremors and paralysis
- Respiratory problems (noise while breathing)
- Heavily muscled
Inheritance and Genotypes
→ HYPP is an autosomal dominant hereditary disease, meaning that horses with one or two copies of the genetic variant (n/HYPP or HYPP/HYPP) are affected.
|Genotype:||The horse is:||Effects:|
|n/n||normal.||The horse does not have any copies of the genetic variant causative for HYPP and therefore cannot pass it on to any offspring.|
|n/HYPP||affected (heterozygous).||The genetic variant causative for HYPP will be passed on to its offspring with a probability of 50%. These 50% will also be affected (n/HYPP).
|HYPP/HYPP||affected (homozygous).||The genetic variant causative for HYPP will be passed on to all offspring. All offspring will also be affected (n/HYPP).|
- Affected animals (n/HYPP or HYPP/HYPP) should not be used for breeding.
Rudolph, J. A., Spier, S. J., Byrns, G., Rojas, C. V., Bernoco, D., & Hoffman, E. P. (1992). Periodic paralysis in quarter horses: a sodium channel mutation disseminated by selective breeding. Nature Genetics, 2(2), 144-147. doi: 10.1038/ng1092-144.
Further information is available at Online Mendelian Inheritance in Animals.