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Hoof Wall Separation Disease (HWSD)

Regular Price: 35,00 € Special Price: 30,00 €

excl. 19% VAT

→ Detachment of the Hoof and Hoofwall.

For a breeder or veterinarian discount please contact us before ordering.

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Product Information

Affected breeds: Connemara Pony and related breeds
Test #: H116
Description: Hoof Wall Separation Disease Genetic Testing

Combo-Package (HWSD+ID test): 50 € (net)

This test detects the single basepair insertion in the SERPINB11 gene.
Samples: Hair, Blood
Time: 10 – 14 days

General Information

  • The first symptoms are commonly noticed within the first year.
  • As the hoofwall separates from the hoof, the horse can become lame.
  • Although some affected horses have minimal symptoms, the worst cases can require euthanasia because of severe pain.

Symptoms

  • Unstabile, brittle hoofwall
  • Inflammation of the hooves
  • Hoof pain

Inheritance and Genotypes

→ HWSD is an autosomal recessive hereditary disease, meaning that horses with only one copy of the genetic variant (N/hwsd) are clinically normal carriers while horses with two copies of the genetic variant (hwsd/hwsd) are affected.

Genotype: The horse is: Effects:
N/N normal. The horse does not have any copies of the genetic variant causative for HWSD and therefore cannot pass it on to any offspring.
N/hwsd a carrier. The horse is clinically normal. The genetic variant causative for HWSD will be passed on to its offspring with a probability of 50%.
hwsd/hwsd affected. The genetic variant causative for HWSD will be passed on to all offspring. All offspring will be carriers (N/hwsd).

Recommendations

  • Carriers may be bred to normal animals (N/hwsd x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or normal.
  • Breeding two carriers (N/hwsd x N/hwsd) is not recommended due to the possibility of 25% of the offspring being affected.
  • Affected animals (hwsd/hwsd) may only be paired with non-carriers (N/N) following a critical review of the breeding value of the animal.

References

Finno, C.J., Stevens, C., Young, A., Affolter, V., Joshi, N.A., Ramsay, S., Bannasch, D.L.: SERPINB11 Frameshift Variant Associated with Novel Hoof Specific Phenotype in Connemara Ponies. PLoS Genet 11:e1005122, 2015. Pubmed reference: 25875171. DOI: 10.1371/journal.pgen.1005122.

Further Information is available on the OMIA website: Online Mendelian Inheritance in Animals.

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