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Foal Immunodeficiency Syndrome (FIS)

35,00 

→ Nonfunctional immune system causes anemia and early death in foals.


Instructions for ordering:

  1. Enter the information of the first horse for which you want to order the test
  2. Add to cart
  3. Go to cart to check out, or
  4. Enter the information for a second horse
  5. For sample collection follow the instructions here.
  6. You can use this template to send in hair samples.
  7. Please also send the completed order form together with the samples.

For a breeder or veterinarian discount please contact us before ordering.

Any information you include here is optional, but will be included on the certificate of results (except “Additional Info”).

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Is there anything else you would like to tell us about your horse? Reason for testing, symptoms etc.?

General Information

  • Antibodies that are usually produced after birth cannot be developed by the impaired immune system.
  • At the age of 3 – 6 weeks, when the foal stopps suckling, maternal antibodies decrease in the foal’s body and infections occur.
  • Anemia usually causes early death or euthanasia of the affected foal.
  • Estimated 10% of Fell ponies and 1% of Dales ponies are affected by FIS (data from UK breed societies).
  • FIS is an autosomal recessive hereditary disease, meaning that horses with only one copy of the genetic variant (N/fis) are clinically normal carriers while horses with two copies of the genetic variant (fis/fis) are affected.

Symptoms

  • Diarrhea
  • Cough
  • Problems suckling
  • Infections
  • Anemia

Inheritance and Genotypes

→ FIS is an autosomal recessive hereditary disease, meaning that horses with only one copy of the genetic variant (N/fis) are clinically normal carriers while horses with two copies of the genetic variant (fis/fis) are affected.

Genotype: The horse is: Effects:
N/N normal. The horse does not have any copies of the genetic variant causative for FIS and therefore cannot pass it on to any offspring.
N/fis a carrier. The horse is clinically healthy. It has one copy of the genetic variant causitive for FIS, which will be passed on to its offspring with a probability of 50%.
fis/fis affected. The pony is affected and will not live long enough to reproduce.

Recommendations

  • Carriers may be bred to normal animals (N/fis x N/N) without any risk of producing affected offspring. The offspring should also be tested before breeding to determine if they are carriers or normal.
  • Breeding two carriers (N/fis x N/fis) is not recommended due to the possibility of 25% of the offspring being affected.

References

Fox-Clipsham, LY., Carter, SD., Goodhead, I., Hall, N., Knottenbelt, DC., May, PD., Ollier, WE., Swinburne, JE.: Identification of a mutation associated with fatal foal immunodeficiency syndrome in the fell and dales pony. PLoS Genet 7:e1002133, 2011. Pubmed reference: 21750681. Doi: 10.1371/journal.pgen.1002133.

Further information is available at Online Mendelian Inheritance in Animals.

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